Asbestos Research Today is a free monthly online journal that collates and summarizes the latest research about Asbestos, including details on mesothelioma, lung disease, dangers, effects, risks.

Cervical endometriosis associated with malignant pleural mesothelioma mimicking cervical cancer--Occam's razor or the "third man".

Engel JB, Heuer S, Segerer S, Rauthe S, Dietl J, Hönig A

Department of Obstetrics and Gynecology, Medical University of Würzburg, Würzburg, Germany. joergbengel@hotmail.com

Published 22 March 2011 in Fertil Steril, 95(5): 1787.e5-7.
Full-text of this article is available online (may require subscription).

Articles on Asbestos published 17 March 2011:

The diagnostic utility of p16 FISH and GLUT-1 immunohistochemical analysis in mesothelial proliferations.   Am J Clin Pathol, 135(4): 619-27.

Two promising ancillary tests used in the diagnosis of mesothelioma include GLUT-1 immunohistochemical analysis and fluorescence in situ hybridization (FISH) testing for the p16 deletion. This study compared the diagnostic usefulness of p16 FISH and GLUT-1 immunohistochemical analysis in the diagnosis of mesothelial proliferations in 158 cases with a diagnosis of benign (45.4%), atypical (10.4%), or malignant/mesothelioma (44.2%). Of the 70 benign cases, none had a deletion of p16 and 5 cases ... [Abstract] [Full-text]

Articles on Asbestos published 9 March 2011:

Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging.   Int J Cancer, 128(9): 2138-46.

Malignant mesothelioma (MM) is a fatal malignancy with a rapidly increasing incidence in industrialized countries because of the widespread use of asbestos in the past centuries. Early diagnosis of MM is critical for a better prognosis, but this is often difficult because of the lack of disease-specific diagnostic imaging. Here, we report that manganese-enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective mesothelioma imaging by monitoring a ... [Abstract] [Full-text]

Articles on Asbestos published 21 February 2011:

Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma.   Cancer Lett, 302(2): 136-43.

Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were ... [Abstract] [Full-text]

Establishment of a cell line from a Japanese patient useful for generating an in vivo model of malignant pleural mesothelioma.   Cancer Sci, 102(3): 648-55.

Malignant pleural mesothelioma is a refractory tumor with increasing incidence. In the present study, we established six mesothelioma cell lines possessing two allele deletions of the p16(INK4A) gene and one allele deletion of the neurofibromatosis type 2 gene, MM16, MM21, MM26, MM35, MM46 and MM56, from pleural effusion fluids or surgically resected tumors of Japanese patients. MM21, MM26 and MM46 cells failed to develop tumors in BALB/c-nude mice following subcutaneous inoculation. MM16 and ... [Abstract] [Full-text]

Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma.   Cancer Lett, 302(2): 136-43.

Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were ... [Abstract] [Full-text]

Articles on Asbestos published 4 February 2011:

The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.   J Pathol, 223(4): 519-30.

The chemokine CXCL12 and its receptors, CXCR4 and CXCR7, are involved in tumour progression, metastasis, and survival. We investigated the expression of CXCR4, CXCL12, and CXCR7 in malignant pleural mesothelioma to determine if they are possible biomarkers and potential therapeutic targets. Forty-one mesothelioma tumour tissues, ten normal human pleural tissues, and two mesothelioma cell lines were stained with anti-CXCR4, anti-CXCL12, anti-CXCR7, and anti-p-Akt antibodies. RT-PCR was performed ... [Abstract] [Full-text]

The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma.   J Pathol, 223(4): 519-30.

The chemokine CXCL12 and its receptors, CXCR4 and CXCR7, are involved in tumour progression, metastasis, and survival. We investigated the expression of CXCR4, CXCL12, and CXCR7 in malignant pleural mesothelioma to determine if they are possible biomarkers and potential therapeutic targets. Forty-one mesothelioma tumour tissues, ten normal human pleural tissues, and two mesothelioma cell lines were stained with anti-CXCR4, anti-CXCL12, anti-CXCR7, and anti-p-Akt antibodies. RT-PCR was performed ... [Abstract] [Full-text]

Articles on Asbestos published 1 February 2011:

A systematic review of lung-sparing extirpative surgery for pleural mesothelioma.   J R Soc Med, 104(2): 69-80.

[Abstract] [Full-text]

© 2004-2011 Asbestos Research Today. All Rights Reserved.